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Central Pain Syndrome is a neurological condition caused by damage specifically to the central nervous system - brain, brainstem, or spinal cord. This is the only up-to-date book available on the clinical aspects (including diagnosis and therapy) of CPS management. The authors have developed a very complete reference source on central pain, which includes background material, pathophysiology, and diagnostic and therapeutic information. A medical mystery for 100 years with no effective cure, this book turns the concept of incurability of central pain on its head, providing a rational approach to therapy based on a rational theory.

作者简介：

Sergio Canavero is the founder of Turin Advanced Neuromodulation Group, a think tank focused on the advancement of neuromodulation.

Vincenzo Bonicalzi is a senior staff member at the Department of Neurosciences at the third largest medical facility in Italy.

List of Tables

Preface (or, the Story of an Idea)

1 Introduction

　Definitions

　History

2　Central Pain of Brain Origin

　Epidemiology and clinical features

　　1. Lesions causing CP and location

　　2. Incidence and prevalence

　　3. Age of onset of CPSP

　　4. Sex distribution of CPSP

　　5. Time to pain onset

　　6. Side of the lesions

　　7. Size of the lesion and CPSP

　　8. Pain distribution

　　9. Quality of pain

　　10. Intensity of pain

　　11. Components

　　12. Evoked pains

　　13. Somatosensory findings

　　14. Sympathetic and other signs and symptoms

　 Special considerations

　　1. Sensory epilepsy

　　2. Parkinson's disease (PD)

　　3. Iatrogenic lesions

3 Central Pain of Cord Origin

　　1. Lesions causing CCP

　　2. Incidence and prevalence

　　3. Age of onset and sex distribution

　　4. Time to pain onset

　　5. Level of lesion

　　6. Distribution of pain

　　7. Quality

　　8. Intensity

　　9. Components

　 10. Evoked pains

　　11. Somatosensory deficits

　　12. Sympathetic and other signs and symptoms

　　13. Course

　Special considerations

　　1. Syringomyelia

　　2. Multiple sclerosis (MS)

　　3. Spinal epilepsy

4 Diagnosing Central Pain

5 Drug Therapy

　 Oral and parenteral drug therapy

　　1. General comments

　　　GABA drugs

　　　Antiglutamatergic agents

　　　Sodium channel blockers

　　　Antidepressants

　　　Opioids, naloxone and cannabinoids

　　　Miscellaneous agents

　　　Combinations

　　2. Drug aggravation of CP

6　Neuromodulation

　　Electrical

　　1. Extra- and subdural motor (MCS) and sensory cortex stimulation (PCS)

　　　Mechanism of action

　　2. Deep brain stimulation (DBS)

　　　Mechanism of action

　　　　a. PAG-PVG

　　　　b. Vc

　　　　c. Other areas

　　　Efficacy

　　　　a. Vc DBS

　　　　b. PAG-PVG DBS

　　3. Spinal cord stimulation

　　　Mechanism of action

　　　Efficacy

　　……

7 Pathophysiology:Human Data

8 Piecing Together the Evidence

References

Index

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书籍介绍

Central Pain Syndrome is a neurological condition caused by damage specifically to the central nervous system - brain, brainstem, or spinal cord. This is the only up-to-date book available on the clinical aspects (including diagnosis and therapy) of CPS management. The authors have developed a very complete reference source on central pain, which includes background material, pathophysiology, and diagnostic and therapeutic information. A medical mystery for 100 years with no effective cure, this book turns the concept of incurability of central pain on its head providing a rational approach to therapy based on a rational theory.